Epidemiology :

Mostly found in the age < 3 years old. Up until now, the etiology is still unknown. The risk of getting this disease is increasing as birth weight decreases.

Pathogenesis :

The disease divided into two ways.
Epithelial type –> containing fetal or embryonal malignant cells
Mixed Type –> containing mesenchymal and epithelial elements

Clinical Manifestation :

- General Manifestations –> Large, asymptomatic malignant cells
Weight loss, anorexia, vomiting, abdominal pain
- If Metastatic, it will spread –> involves regional lymph nodes and the lungs

Lab :
- ?-fetoprotein elevated
- Bilirubin and Liver enzymes Normal

Diagnosis :
- Plain radiographs
- USG
- CT / MRI

Treatment :
- Depends on complete resection of the primary tumor
- Cisplatin + vincristine and 5-fluorouracil or doxorubicin

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